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Wuhan Wang Lianshang Biotechnology Co., Ltd.

Epithalon, Epitalon, Anti-Aging manufacturer / supplier in China, offering Pharmaceutical Grade Epithalon Powder Pepdites Epitalon 99% Anti-Aging 307297-39-8, Semi-Finished Injectable Oil Testosterone Propionate/Test Prop for Muscle Growth CAS 57-85-2, 99% Manufacturer Supply High Quality Industrial Salt/Sodium Chloride and so on.

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Supplier Homepage Product Peptide and Human Growth Steroid Pharmaceutical Grade Epithalon Powder Pepdites Epitalon 99% Anti-Aging 307297-39-8

Pharmaceutical Grade Epithalon Powder Pepdites Epitalon 99% Anti-Aging 307297-39-8

FOB Price: US $220 / mg
Min. Order: 10 mg
Min. Order FOB Price
10 mg US $220/ mg
Get Latest Price
Transport Package: 10mg/Bottle
Payment Terms: T/T, Western Union, Money Gram, Bitcoin
Basic Info
  • Model NO.: CAS: 307297-39-8
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: >98%
  • Origin: China
  • Powder: Yes
  • Certification: ISO 9001, USP
  • State: Solid
  • Specification: white powder
Product Description
Pharmaceutical Grade Epithalon Powder Pepdites Epitalon 99% Anti-Aging 307297-39-8
(Epitalon) 10mg 
Basic Details:
Product Name: Epithalon
Synonyms: Epitalon ; Epithalone
CAS: 307297-39-8 
MF: C14H22N4O9 
MW: 390 
Usage: Tetrapeptide revealing geroprotective effect.

Description:
Epithalon (also known as Epitalon or Epithalone) is the synthetic version of the polypeptide Epithalamin which is naturally produced in humans. This pineal peptide preparation is secreted in the epithlamium-epiphyseal region of the brain. Its more prominent tasks are: to regulate metabolism in the epiphysis, increase the sensitivity of hypothalamus to its natural hormonal influences, normalize the function of the anterior pituitary, regulate the levels of gonadotropins and melatonin in the body. Epithalamin increases a person's resistance to emotional stress and also acts as an antioxidant. 

Epithalamin was first discovered in the late 1980's by Prof. Vladimir Khavinson from St. Petersburg, Russia. It has been studied extensively ever since. It is known by several names, including Epitalon, Epithalon, Epithalone, Epithalamin and Epithalamine. Since all the patents are held by the Russian inventor there is not much interest for this tetra-peptide from the western big pharma industry. This makes the substance fairly unknown in the west due to the absence of marketing usually seen with big pharma products. In Russia it is currently in clinical studies and shows prospective results as treatment for liver disorders, neuropathology, psychiatry and geriatrics.

The title compound was obtained by solution-phase peptide synthesis. Acylation of L-aspartic acid beta-benzyl ester (II) with the succinimidyl ester of N-Boc-gamma-benzyl-L-glutamic acid (I) led to the protected dipeptide (III). Removal of the Boc protecting group of (III) by means of trifluoroacetic acid afforded amine (IV), which was subsequently condensed with N-Cbz-L-alanine succinimidyl ester (V) to furnish tripeptide (VI). Coupling of (VI) with glycine benzyl ester (VII) using DCC and HOBt gave the fully protected peptide (VIII). The N-Cbz and benzyl ester groups of (VIII) were finally removed by catalytic hydrogenation over Pd/C to provide the target tetrapeptide.
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