Pharmaceutical Steroid Powder Source CAS 4759-48-2 Isotretinoin for Treat Cystic Acne
|FOB Price:||US $1 / Piece|
|Min. Order:||1 Piece|
|Min. Order||FOB Price|
|1 Piece||US $1/ Piece|
|Port:||Hong Kong, Hong Kong|
|Production Capacity:||100 T /Month|
|Payment Terms:||T/T, Western Union, Money Gram|
- Model NO.: 4759-48-2
- Customized: Non-Customized
- Suitable for: Elderly, Adult
- Purity: >99%
- Delivery: Within 24 Hours After Payment Confirmed
- Shiping Port: Shanghai, Shenzhen, Canton, Guangzhou
- Transport Package: Discreet Package
- Origin: China
- Powder: Yes
- Certification: ISO 9001, USP, BP
- State: Solid
- Property: White Crystals
- Shipment: EMS, FedEx, TNT, DHL, UPS
- Trademark: Wang Lianshang
- Specification: COA
- HS Code: 218
English name: isotretinoin
Alias: 13-cis-retinoic acid; 13-cis-vitamin a acid; 3,7-dimethyl-9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2-cis-4-trans -6-trans-8-trans-nonatetraenoic acid; (13cis) -15-oxidoretinal
EINECS Number: 225-296-0
Melting point: 174-177 ºC
Boiling point: 462.8 ° C at 760 mmHg
Flash Point: 350.6 ° C
Vapor Pressure: 7.55E-10mmHg at 25 ° C
Uses:For the treatment of severe acne embolism
Appearance:yellow crystalline powder
Isotretinoin , also known as 13-cis retinoic acid, is an oral pharmaceutical drug primarily used to treatsevere nodular acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.
Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a transient worsening of acne (lasting 2-3 weeks), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn. Uncommon and rare side effects include muscle aches and pains (myalgias), and headaches.
Isotretinoin is known to causebirth defects due to in utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development.
Isotretinoin was first marketed as Accutane by Hoffmann-La Roche. It sold well for many years, but in 2009, Roche decided to remove Accutane from the US market after juries had awarded millions of dollars in damages to former Accutane users over inflammatory bowel disease claims. Other common brands are Roaccutane (Hoffman-La Roche, known as Accutane in the United States before July 2009),Amnesteem (Mylan),Claravis (Teva),Absorica (Ranbaxy),Isotroin (Cipla), and Epuris (Cipher).
Vitamin A class drugs. It can rapidly and strongly inhibit the cell proliferation and differentiation process of skin glands cells. It has a high effect on severe nodular cystic acne. This product has a high gastrointestinal absorption, but invalid for topical administration. It is used for treating severe acnes which cannot be treated by other drugs. It also has some effects on treating cystic acne, the party of acne, rosacea, ichthyosis, follicular keratosis and pityriasis red hair and other skin diseases.
Isotretinoin is an effective drug against acne. It takes effect on four processes of acne procedures, preventing the formation of acne lesions: inhibiting sebaceous secretion; inhibit the growth of acne bacillus; inhibiting sebaceous hyperplasia; anti-inflammatory effect. Isotretinoin has no affinity to Vitamin A acid receptors. Its exact mechanism of action is not very clear. Its anti-acne role may be related to that it or its metabolites can inhibit the proliferation and differentiation of sebaceous glands. Isotretinoin belongs to the first generation of vitamin A acid. It is a stereoisomer of all-trans vitamin A acid. Oral administration has an anti-oil effect which has special effect on severe acne.
It may also reduce the volume of the sebaceous glands, reducing the skin's DHT, down-regulate the expression of skin androgen receptor. Other possible mechanism includes reducing the hair follicle keratosis, antibacterial, anti-inflammatory effects and so on. In the 1980s, Isotretinoin is only for treating severe nodular cystic acne. Isotretinoin is now also used for treating some less-seriously acne where those related patients are often insensitive to conventional therapy, especially some patients with long-term use of antibiotics due to that acne bacillus have evolved multiple drug (such as erythromycin, ) resistance. It may also be used for some acne patients prone to scar.
Dosage and Administration:
Doses are usually within the range of 0.5-1.0 mg per day,however your doctor will determine your individual requirements.If you have problems with your kidneys then your doctor will give you a lower dosage.
The capsules should be taken once or twice a day with food.Swallow the capsules whole without chewing or sucking them.
Sotre at 20ºC-25ºC,excursion permitted between 15ºC-30ºC.Protect from light.
DO NOT EXCEED THE STATED DOSE.
KEEP MEDICINE OUT OF THE SIGHT AND REACH OF CHILDREN.
|Product name||Isotretinoin (13-cis Vitamin A acid)|
|Date of manufacturing||2th, July, 2016||Shelf life||1th, July, 2018|
|Appearance||Yellow or orange crystalline powder||Complies|
|Loss on drying||Not more than 0.5%||0.05%|
|Residue on ignition||Not more than 0.1%||0.02%|
|Heavy metals||Not more than 0.002%||<0.002|
|Tretinoin||Not more than 1.0%||0.1%|
Pharmaceutical Raw Materials:
Pharmaceutical Raw Material
Dexamethasone sodium phosphate
4-Amino -5-chloro-2-ethoxy-N- benzamide
Ciclopirox Olamine Ointment
Nafcillin Sodium Salt Monohydrate
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