Glutathione (L-glutathione Reduced, GSH) CAS 70-18-8 GMP Pharmaceutical Material
|FOB Price:||US $1 / KG|
|Min. Order:||10 grams|
|Min. Order||FOB Price|
|10 grams||US $1/ KG|
|Transport Package:||1kg Foil Bag or as Your Requirement|
|Payment Terms:||T/T, Western Union, Money Gram|
- Model NO.: 70-18-8
- CAS No.: 70-18-8
- Einecs: 200-725-4
- Appearance: White or Almost White, Crystalline Powder
- Specification: ISO9001, KOSHER, SGS
- HS Code: 3001884
- Product Name: Glutathione
- Assay: 99%
- Export Markets: Global
- Trademark: Network Union
- Origin: China
High quality Glutathione(Reduced L-Glutathione)
Synonyms: Glutathione(8CI); Glutathione, L-Glutathione; Glutathione-SHL-Glutathione; ; L-Glutathione Reduced
Molecular Weight: 307.36
Appearance: White crystal powder
Packing: Aluminium Bags with Zip Lock Bags Inside
Production Capacity: 1ton Per Year
HS Code: 2938999099
Density: 1.441 g/cm3
Melting Point: 192-195 °C (DEC. )(lit. )
Boiling Point: 754.492 °C at 760 mmHg
Flash Point: 410.102 °C
Solubility: Soluble in water
What is Glutathione reduced?
Glutathione is glutamic acid, cysteine and glycine combination of the three peptides, cysteine thiol on its active groups, glutathione has also prototype (G-SH) and oxidized type (GSSG) form, under physiological conditions to the majority of reduced glutathione, glutathione (GSH) is the main activity of the state, accounting for 95%; oxidized glutathione (GSSG) about 1% of the non-active state. Glutathione reductase catalyzing the interaction between the two types change. Coenzyme enzyme for the metabolism of sugar phosphates bypass provides NADPH.
The glutathione powder can remove free radicals in human cells;
The glutathione powder can combine toxic substances in the human body and then be removed out of the human body;
The glutathione powder can activate and protect immune cells and strengthen the immunologic function of the humanbody;
The glutathione powder can affect the activity of tyrosinase in skin cells, inhibit the generation of melanin and avoid the formation of skin splash;
The glutathione powder to anti-allergy, or inflammation caused by hypoxemia in patients with systemic or local, can reduce cell damage and promote repair.
Glutathione exists in both reduced (GSH) and oxidized (GSSG) states. In the reduced state, the thiol group of cysteine is able to donate a reducing equivalent (H++ e?) to other unstable molecules, such as reactive oxygen species. In donating an electron, glutathione itself becomes reactive, but readily reacts with another reactive glutathione to form glutathione disulfide (GSSG). Such a reaction is probable due to the relatively high concentration of glutathione in cells (up to 5 mM in the liver).
GSH can be regenerated from GSSG by the enzyme glutathione reductase (GSR): NADPH reduces FAD present in GSR to produce a transient FADH-anion. This anion then quickly breaks a disulfide bond (Cys58 - Cys63) and leads to Cys63's nucleophilically attacking the nearest sulfide unit in the GSSG molecule (promoted by His467), which creates a mixed disulfide bond (GS-Cys58) and a GS-anion. His467 of GSR then protonates the GS-anion to form the first GSH. Next, Cys63 nucleophilically attacks the sulfide of Cys58, releasing a GS-anion, which, in turn, picks up a solvent proton and is released from the enzyme, thereby creating the second GSH. So, for every GSSG and NADPH, two reduced GSH molecules are gained, which can again act as antioxidants scavenging reactive oxygen species in the cell.
In healthy cells and tissue, more than 90% of the total glutathione pool is in the reduced form (GSH) and less than 10% exists in the disulfide form (GSSG). An increased GSSG-to-GSH ratio is considered indicative of oxidative stress.
Glutathione has multiple functions:
1.It is the major endogenous antioxidant produced by the cells, participating directly in the neutralization of free radicals and reactive oxygen compounds, as well as maintaining exogenous antioxidants such as vitamins C and E in their reduced (active) forms.
2.Regulation of the nitric oxide cycle is critical for life, but can be problematic if unregulated.
3.It is used in metabolic and biochemical reactions such as DNA synthesis and repair, protein synthesis, prostaglandin synthesis, amino acid transport, and enzyme activation. Thus, every system in the body can be affected by the state of the glutathione system, especially the immune system, the nervous system, the gastrointestinal system, and the lungs.
4.It has a vital function in iron metabolism. Yeast cells depleted of or containing toxic levels of GSH show an intense iron starvation-like response and impairment of the activity of extramitochondrial ISC enzymes, followed by death.
|Assay by HPLC:||99.0%||99.20%|
|Appearance:||White crystalline or White powder||Complies|
|State of solution:||Clear and colorless||Complies|
|Specific rotation:||-15.5~ -17.5||-17.0|
|Loss on drying %:||≤0.50%||0.22%|
|Heavy metals PPM:||<7ppm||Complies|
|Total Plate Count:|
Yeast & Mold:
|Conclusion:||Conform with specification |
Packaging & Delivery:
We have professional team for package and shipment. Special way to ship 100 grams to 100kg powders at one time to your country. Fast and discreet shipment could be arranged for customs pass Guaranteed.
Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.
Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.
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