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Rad-140, 118237-47-0, Rad-140 Powder manufacturer / supplier in China, offering Good Quality Androgen Steroids CAS 118237-47-0 Rad-140 for Bodybuilding, GMP Pharmaceutical Manufacturer Levetiracetam 102767-28-2, Chemical Cosmetics 501-30-4 China Kojic Acid for Skin Care and so on.

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Good Quality Androgen Steroids CAS 118237-47-0 Rad-140 for Bodybuilding

FOB Price: US $1 / g
Min. Order: 10 g
Min. Order FOB Price
10 g US $1/ g
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Production Capacity: 500 Tons
Transport Package: 1kg/Aluminum Foil Bag or as Your Requirement
Payment Terms: T/T, Western Union, Money Gram

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Basic Info
  • Model NO.: 118237-47-0
  • CAS No.: 118237-47-0
  • Export Markets: Global
  • Delivery: 5-7 Working Days Door to Door
  • Payment: Western Union, Moneygram, Bank Transfer
  • Production Origin: China
  • Specification: SGS, ISO9001, KOSHER
  • HS Code: 3001
  • Product Name: Rad-140
  • Appearance: White Powder
  • Polciy: Re-Shipping Policy
  • Assay: 99%
  • Shipping Ways: EMS, TNT, FedEx, DHL, by Air, etc
  • Trademark: Network Union
  • Origin: China
Product Description
The androgen receptor (AR) is a member of the steroid hormone nuclear receptor superfamily that includes estrogen, progestin, glucocorticoid and mineralocorticoid receptors.1 The binding of the prototypical, endogeneously produced androgen testosterone (1) and the important active metabolite dihydrotestosterone (2) to AR initiates a remarkably diverse array of biological activities that can vary according to a subject's sex, age and hormonal status. The activity of AR is critical to normal human sexual development and function, but beyond this signature role, AR activation also has important effects on diverse targets such as bone, liver, muscle and the central nervous system.2,3 The therapeutic potential of androgen signaling is well-appreciated in the medicinal chemistry community, and for quite some time, chemists have sought compounds that selectively stimulate muscle and bone growth while minimizing the proliferative and/or hypertrophic effects on sex tissues such as the prostate in males and clitoris in females.4,5 Such compounds have been termed selective androgen receptor modulators or SARMs. In this regard, the prototypical and endogenous androgen, testosterone, is considered to be a logical benchmark comparator. Compound 3 is the GTx SARM S-22 and compound 4 is the BMS SARM 562929, both of which have been reported in the literature as being orally active compounds with selectivity for muscle over prostate relative to testosterone in various preclinical models.6,7
The possibility of obtaining compounds having tissue-selective activities that are different from that of the endogenous benchmark testosterone might derive from the fact that typical AR receptor activation, which is initiated by the binding of a molecule with affinity for the AR to the AR ligand binding domain, is then followed by a rather remarkable, coordinated series of interactions: These may include a change in receptor topology, dissociation of heat shock proteins, receptor dimerization, receptor phosphorylation, rapid-signaling events, translocation to the nucleus (AR), association with many different coregulatory proteins to form a transcriptional complex that results in the activation or suppression of RNA synthesis from AR-modulated genes, and finally receptor degradation.8 Since each receptorligand complex topology is unique to that ligand structure, one can appreciate that the interaction of any particular ligandreceptor complex with coregulatory proteins is likely to be unique to that ligand as well. Furthermore, because the expression level of AR, the constellation and expression level of coregulatory proteins, and the patterns of post-transcriptional regulatory events differ in each type of androgen target cell, and the topography of AR regulatory sites in the genome differs at each gene, this remarkable choreography of events and interactions provides a rich environment within which one might search for SARMs having a desirable pattern of tissue-selective pharmacology, such as high anabolic but limited androgenic activity.
Further complicating our understanding of the origin of SARM selectivity is the "bio-amplification" of the primary endogenous androgen testosterone. Interestingly, the endogenously produced and very important androgen testosterone serves as a type of "anti-SARM" or "inverse SARM" because its androgenic activity is increased by conversion to the more potent 5α-dihydrotestosterone by the 5α-reductase enzyme in certain tissues including the scalp and prostate (but not in muscle or bone). As a result, androgens that do not undergo such bioamplification in the prostate will demonstrate improved selectivity regarding muscle vs prostate when compared to a testosterone-treated control or an intact animal whose primary endogenous androgen is testosterone.9 More broadly put, one might appreciate that metabolic differences between endogenous androgens such as testosterone or dihydrotestosterone and SARMs can also vouch for at least some selectivity differences.
Our work in the SARM area resulted in the synthesis and evaluation of a large number of candidate templates. While we found it relatively easy to obtain compounds with high affinity for AR, we struggled to achieve compounds that demonstrated good oral efficacy and high in vivo tolerability. After scanning many potential leads for oral, in vivo activity, we arrived at high affinity compound 5 through a combination of synthetic intermediate testing, literature evaluation and fragment combination. We were delighted when 5 demonstrated oral activity in rats.
However, when we performed a pharmacokinetic analysis in rats, we could detect only very low levels of 5 after oral dosing (F < 5%). Further analysis revealed that 5 was efficiently converted to 6in vivo, presumably by cytochromes P450 in the rat liver.10 Compound 6 had similar activity to compound 5in vivo, suggesting that 6was largely responsible for the activity of compound 5.11 An in vitro screen with human microsomes revealed rapid metabolism of compound 5, thus indicating this transformation as a potential human metabolic liability and prompting us to prepare compounds in which the 4′-position of the pendant phenyl was blocked from P450-induced hydroxylation.12 We looked at several analogues containing a 4′-blocking group, and in the course of our efforts we identified compound 7 (RAD140; Figure Figure1)1) as our preclinical development candidate.


Packaging & Delivery:

1).Our prefessional team  Continued for  innovation, transformation,has developed our own packaging features,this safe packing  can  ensure 100% pass customs
2).Resent policy is available (Depends on the  situation  )that guarantee every customer  interests.
3).Delivery Within 24 hours after payment, usually  just take 3-5 days received when  shipped
(4).Shipping  ways:Ems,Tnt ,Fedex,Dhl,By Air ,etc,
(5).Payment  terms:Western Union, Moneygram, Bank Transfer
 
Steroids Order Processing
 

Items
Content
Make an orderState what kind of steroids and quantity for each powder you want
ShippingProvide your addressee info ( phone number )
PackingChosen according to your country and quantity of order
DeliveryArranged within 12 hours upon receipt of your payment
PhotosPhotos of parcel would be offered to tell apart the steroids .
Tracking numberOffered once it is released
After-sale service24/7 online for your all kinds of steroids powder problems

4-CMC
5a Hydroxy Laxogenin 
Formestane
Anablicum (LGD-4033)
Andarine (S4)
GW501516 (GW1516 or GSK-516)
Ostarine (MK-2866)
Nutrobal (Mk-677)
LGD-4033
Sunifiram (DM-235)
GSH (Glutathione)
Epistane Havoc
Dymethazine DMZ (Mebolazine)
M1,4ADD 
M1T

 


Product name
CAS NO.Product nameCAS NO.
Benzocaine94-09-7Procaine59-46-1
Dapoxetine Hydrochloride129938-20-1Tetracaine HCl136-47-0
Clobetasol Propionate25122-46-7L-Thyroxine51-48-9
Finasteride98319-26-7Dydrogesterone152-62-5
Theophylline58-55-9/ 5967-84-0Valdecoxib181695-72-7
Azithromycin117772-70-0  
Procaine HCl51-05-8Lidocaine HCl73-78-9
Lidocaine137-58-6 50-02-2
Dapoxetine119356-77-3L-Epinephrine hydrochloride55-31-2/ 329-63-5
Chloramphenicol56-75-7/ 2787-09-9Doxorubicin hydrochloride25316-40-9
Benzyl alcohol100-51-6Paclitaxel33069-62-4
Omeprazole73590-58-6/ 119141-89-8Benzyl benzoate120-51-4
Dutasteride164656-23-9Cyanocobalamin68-19-9/18195-32-9/13408-78-1
Benzocaine HCl23239-88-5Furazolidone67-45-8
Formestane566-48-3Rifaximin80621-81-4
Acetaminophen103-90-2Paromomycin7542-37-2
Amikacin disulfate salt39831-55-5/ 149022-22-0Nitazoxanide55981-09-4
Dexamethasone sodium phosphate55203-24-2/ 312-93-6Secnidazole3366-95-8
Trestolone acetate6157-87-5Tinidazole19387-91-8
Lincomycin hydrochloride7179-49-9Chlorhexidine Gluconate18472-51-0
Clotrimazole23593-75-1
1,3-dimethyl-pentylamine

hydrochloride
 
13803-74-2
1,3-Dimethylbutylamine hydrochloride
71776-70-0

 
 
4 amino-2-Methylpentane citrate (AMP Citrate)NP

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1: Professional Producer in Aseptic production workshop
2: Professional analysis people to control quality.
3: Professional seller to keep good business with you
4: Professional forwarders to carry with the shipping.

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