Epithalon CAS: 307297-39-8 Muscle Growth Peptide Powder
|FOB Price:||US $1 / Piece|
|Min. Order:||10 Pieces|
|Min. Order||FOB Price|
|10 Pieces||US $1/ Piece|
|Transport Package:||2mg/Vials, 10 Vials/Box|
|Payment Terms:||L/C, T/T, Money Gram|
- Model NO.: 307297-39-8
- Other Name: Epithalon Tetra Peptide;Epitahlon
- Molecular Formula: C14h122n4o9
- Purity: 99%
- Appearance: White Powder
- Specification: ISO9001
- HS Code: 98565475
- Product Name: Epithalon
- CAS: 307297-39-8
- Molecular Weight: 390.34588
- Delivery Time: 4-8 Working Days
- Trademark: Network union
- Origin: China
Epitalon Tetra Peptide
Epithalon is a peptide used to regulate the cell cycle through up-regulation of telomerase activity. The sequence of amino acids in the peptide is Alanine-Glutamate-Asparagine-Glycine. Animal studies have been done on the effects of Epithalon on suppression of spontaneous mammary tumors and spontaneous carcinogenesis. Studies have shown that the mode of action of Epithalon involves suppression of oncogene expression and modification of telomerase activity. A summary of the studies and research on telomerase is provided below.
|Synonyms||Epithalon Tetra Peptide, Epitalon, Epitahlon|
|Reports||Certificate of Analysis|
|Terms||The products we offer are intended for laboratory research use only. Please familiarize yourself with our Terms and conditions prior to ordering.|
Telomerase is a specific RNA (ribonucleic acid)-dependent polymerase that elongates and maintains the length of telomeres by adding tandem repeats on the chromosomal 3' end. The enzyme is composed of two parts: an RNA component which supplies the telomere template for elongation, and the catalytic subunit which possesses reverse transcriptase activity. These two parts work in tandem to avert telomere attrition especially in somatic cells. In vitro experiments have shown that telomere elongation promotes indefinite cellular proliferation and that suppression of telomerase activity promotes apoptosis of neoplastic cells. However, these studies have also shown that maintenance of telomere length within a range of 15-20 kilobase pairs does prevent tumorigenesis. All the research and studies done concerning telomerase do show that telomerase activity is limited to cell division through its action of stabilizing the telomere length.
Telomeres are located at either ends of a chromosome, and they do protect the adjacent gene sequence from shortening due to repeated replication cycles. Elongation of telomeres enables senescent cells to stabilize their telomeric length. However, excess elongation would enable such cells to exceed their Hayflick limit via evasion of apoptosis or the post-mitotic phase; and therefore, such cells have the potential of becoming immortal and this predisposes them to neoplastic transformation.
Human telomeres are made up of tandem repeats of the nucleotide sequence TTAGGG that form a T loop structure when associated with telomere-binding proteins. The T loop structure ensures the integrity of the telomeres by protecting them from constitutive degradation. These tandem repeats do shorten as a consequence of repeated chromosomal replication cycles. Such shortening is due to the inability of DNA polymerase to repeatedly replicate the nucleotides located in the T loop region. This leads to senescence or growth arrest, and a critically shortened telomere does induce a p53-mediated DNA checkpoint reaction. Some cells do evade senescence if they have nonfunctional p53 and/or pRb, but cell death still occurs due to either lethal DNA rearrangements or chromosomal fusion. Thus, evasion of telomere-mediated senescence is the main way that cells use to avert premature senescence and apoptosis. This occurs only when telomerase activity is up-regulated. Telomerase elongation leads to stabilization of the genotype as the rate of gene mutation is maintained within normal limits. However, an increase in the rate of apoptosis leads to a proportionate increase in cellular regeneration rate, and this causes an increase in the number of sporadic gene mutations that occur thus predisposing the person to pro-neoplastic mutations.
Current studies show that telomere shortening is associated with chronic diseases such as pulmonary fibrosis, coronary artery disease, diabetes mellitus and Alzheimer's disease, though their findings are still considered inconclusive. Based on the findings of these studies, it can be theorized that Epithalon could prevent the development of these diseases.
Epithalon Tetra Peptide
Epithalon Tetra Peptide Sequence: alanyl-glutamyl-aspartyl-glycine
Molecular Formula: C14H22N4O9
Molecular Weight: 390.34588
Product list for Peptide Powder:
|T-A001||MGF||2mg/vials, 10 vials/box|
|T-A002||PEG MGF||2mg/vials, 10 vials/box|
|T-A003||CJC-1295 with DAC||2mg/vials, 10 vials/box|
|T-A004||CJC-1295 without DAC||2mg/vials, 10 vials/box|
|T-A005||PT-141||10mg/vials, 10 vials/box|
|T-A006||MT-1||10mg/vials, 10 vials/box|
|T-A007||MT-2||10mg/vials, 10 vials/box|
|T-A008||GHRP-2||5mg/vials, 10 vials/box|
|T-A008||GHRP-2||10mg/vials, 10 vials/box|
|T-A009||GHRP-6||5mg/vials, 10 vials/box|
|T-A009||GHRP-6||10mg/vials, 10 vials/box|
|T-A010||Ipamorelin||2mg/vials, 10 vials/box|
|T-A011||Hexarelin||2mg/vials, 10 vials/box|
|T-A012||Sermorelin||2mg/vials, 10 vials/box|
|T-A013||Oxytocin||2mg/vials, 10 vials/box|
|T-A014||TB500||2mg/vials, 10 vials/box|
|T-A015||pentadecapeptide BPC 157||2mg/vials, 10 vials/box|
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|T-A017||Triptorelin||2mg/vials, 10 vials/box|
|T-A018||Tesamorelin||2mg/vials, 10 vials/box|
|T-A020||Gonadorelin||2mg/vials, 10 vials/box|
|T-A020||Gonadorelin||10mg/vials, 10 vials/box|
|T-A021||DSIP||2mg/vials, 10 vials/box|
|T-A022||Selank||5mg/vials, 10 vials/box|
|T-A023||Follistatin 344||1mg/vials,10 vials/box|
|T-A024||FOLLISTATIN 314||1mg/vials,10 vials/box|
|T-A025||ACE 031||1mg/vials,10 vials/box|
|T-A028||AOD9604||5mg/vials, 10 vials/box|
|T-A029||Epithalon||10mg/vials, 10 vials/box|
|T-A030||SNAP-8||5mg/vials, 10 vials/box|
Packaging & Delivery:
We have professional team for package and shipment. Special way to ship 100 grams to 100kg powders at one time to your country. Fast and discreet shipment could be arranged for customs pass Guaranteed.
Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.
Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.
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Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.
High quality, good price, fast and safety delivery. Shipment by DHL, TNT, FEDEX, HKEMS, UPS, etc.