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Wuhan Wang Lianshang Biotechnology Co., Ltd.

Melanotan, Melanotan I, Melanotan 1 manufacturer / supplier in China, offering Tanning Peptide Melanotan 1 (Melanotan I) CAS 75921-69-6 10mg, Quality Guaranteed Raw Powder and Injectable 250mg/Ml Enanject 250 Testosterone Enanthate, 100% Purified Hot Sell Muscle Building Steroid Deca 200 Nandrolone Decanoate Steroid Hormone Powder and so on.

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Supplier Homepage Product Peptide and Human Growth Steroid Tanning Peptide Melanotan 1 (Melanotan I) CAS 75921-69-6 10mg

Tanning Peptide Melanotan 1 (Melanotan I) CAS 75921-69-6 10mg

FOB Price: US $1 / vial
Min. Order: 10 vial
Min. Order FOB Price
10 vial US $1/ vial
Get Latest Price
Production Capacity: 8000 Vial/Month
Transport Package: Foil Bag, Dum
Payment Terms: T/T, Money Gram, Western Union, Bitcoin
Basic Info
  • Model NO.: 75921-69-6
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >99%
  • Unit Size: 10 Mg/Vial
  • Synonyms: Melanotan , Melanotan I, Mt 1, Mt I
  • Physical State: Lyophilized Powder
  • Trademark: NWU
  • Origin: China
  • Powder: Yes
  • Certification: ISO 9001, USP, BP
  • State: Lyophilized Powder
  • Product Name: Melanotan
  • CAS No: 75921-69-6
  • Sequence: AC-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-P
  • Solubility: Soluble in Water or 1% Acetic Acid
  • Specification: SGS, ISO9001
  • HS Code: 3001
Product Description

Melanotan-1 Peptide Amino Acid Sequence:
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Molecular formula: C78H111N21O19
Molar Mass: 1646.845
CAS number: 75921-69-6
PubChem: CID 16154396
Synonyms: Melanotan; Melanotan-1; Melanotan I; CUV1647; EPT1647; NDP-MSH; [Nle4, D-Phe7]α-MSH
[Nle4, D-Phe7]-α-MSH Melanotan
 
 

Product Name:

Melanotan

 Unit size:

10 mg/vial

 CAS NO.:

75921-69-6

 Synonyms:

Melanotan , Melanotan I, MT 1, MT I

 Sequence:

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

 Purity:

≥98% (HPLC)

 Physical State:

Lyophilized Powder

 Solubility:

Soluble in water or 1% acetic acid

 Storage:

Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18°C. Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°C.

 
 
The Development of Melanotan 1
 
The initial creation of the Melanotan 1 peptide tanning analogue can be credited to the University of Arizona. During the course of study aimed at developing a defense against skin cancer, focus was placed on developing a method of stimulating natural melanogenesis, or the natural production of melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight. Initially, University of Arizona researchers attempted to directly administer the naturally occurring hormone alpha-MSH in order to elicit this desired result. Although this strategy exhibited promising results, it was determined that the naturally occurring MSH had a prohibitively short half-life to be of realistic use as a therapeutic remedy. However, the positive results gleaned from MSH administration encouraged further research into the development of Melanotan 1, which exhibits similar effects whilst possessing an extended half-life for functional therapeutic utilization. The researchers, headed by Victor J. Hruby and Mac E. Hadley, found a peptide, [Nle4, D-Phe7]-α-MSH, that was approximately 1,000 times more potent than natural α-MSH. They named this new peptide molecule "Melanotan" (later Melanotan-1).
 
 
 
Melanotan-1 Mechanism of Action - How it Works!
 
Melanotan produces its photoprotective effects by triggering a 'signaling cascade' via its activation of the MC1R on melanin-producing cells known as melanocytes. Upon Melanotan binding with the MC1R on the surface of melanocytes in the epidermal layer of the skin, it begins a series of actions and reactions that result in melanocytes favoring the production of eumelanin (photoprotective black/brown pigment). The initial binding activates the MC1R leading to the activation of adenylate cyclase (AC) and stimulation of the production of cyclic adenosine monophosphate (cAMP). cAMP in turn activates protein kinase A (PKA) resulting in the phosphorylation of the cAMP response element-binding (CREB). Phosphorylated CREB will bind to the cAMP response element (CRE) on the microphthalmia-associated transcription factor (MITF) gene leading to the synthesis of the MITF protein. MITF has the ability to activate several genes by binding to them, including the MC1R gene and the genes involved in melanogenesis. This results in increased concentrations of the melanogenic enzymes within the melanocyte.
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